Gartlehner, G;
Dobrescu, A;
Chapman, A;
Toromanova, A;
Emprechtinger, R;
Persad, E;
Affengruber, L;
Pieh, C;
Klerings, I;
Wagner, G.
Primary care patients and clinicians may prefer alternative options to second-generation antidepressants for major depressive disorder (MDD). To compare the benefits and harms of nonpharmacologic treatments with second-generation antidepressants as first-step interventions for acute MDD, and to compare s...
This first update alert reports the surveillance results of the living systematic review on “Nonpharmacologic and Pharmacologic Treatments of Adult Patients With Major Depressive Disorder: A Systematic Review and Network Meta-analysis for a Clinical Guideline by the American College of Physicians” (1...
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Evidence-based recommendations on nivolumab (Opdivo) with platinum- and fluoropyrimidine-based chemotherapy for untreated HER2-negative advanced gastric, gastro-oesophageal junction or oesophageal adenocarcinoma in adults.
Commercial arrangement
There is a commercial access agreement for nivolumab...
Evidence-based recommendations on transcutaneous electrical stimulation of the trigeminal nerve for ADHD. This involves a single-use electrode patch stuck to the forehead, which sends small electrical pulses through the skin during sleep.
Is this guidance up to date?
Next review: 2026...
Evidence-based recommendations on percutaneous image-guided cryoablation of peripheral neuroma for chronic pain. This involves using a needle-like probe to freeze and destroy small parts of nerves in neuromas to stop the pain signals.
Is this guidance up to date?
Next review: 2026...
Now that the majority of people living with HIV take combination antiretroviral therapy (ART), the
spectrum of causes of pyrexia of unknown origin (PUO) has changed compared with the pre-ART era.
In these guidelines, we focus on causes and evaluation of PUO among people living with HIV with
CD4 counts <3...
La presente Guía de Práctica Clínica (GPC) fue impulsada por la DNAIENT, en el marco de las políticas
que el Ministerio de Salud de la Nación lleva adelante para reducir la morbimortalidad asociada a
las enfermedades no transmisibles y sus factores de riesgo, y reemplaza a la versión precedente del...
La pancreatitis aguda es la inflamación del páncreas que se caracteriza por dolor abdominal
epigástrico intenso y persistente con niveles elevados de enzimas pancreáticas en la sangre (1,
2). La pancreatitis aguda tiene una incidencia anual que varía de 4.9-73.4 casos por 100 000
habitantes a nivel ...
Porucha autistického spektra (PAS) je široce definované neurovývojové onemocnění postihující děti, mladé, ale i dospělé osoby. Projevuje se nesnázemi v sociální interakci (komunikaci), repetitivními (opakujícími) se vzorci v chování a restriktivními (omezenými) zájmy. Může posti...
Electrotherapy can be used to provide pain relief in a range of conditions including osteoarthritis. Although Transcutaneous Electrical Nerve Stimulation (TENS) was recommended as an intervention to consider in NICE Osteoarthritis guideline CG177 it is not thought to be widely used within the NHS. TENS i...
