Cancer can be seen as a chronic disease that requires long-term efforts to address the late effects of treatment and to maximize the health outcomes of survivors. Clinicians, experts and healthcare system leaders in the Hamilton Niagara Haldimand Brant region of Ontario, much like those working in other jurisdictions, are grappling with how best to plan and coordinate these long-term efforts. This evidence brief, and the stakeholder dialogue it was prepared to inform, were designed to support their actions. The hope is that the lessons learned from this demonstration area can inform developments in other regions across the province of Ontario and at the provincial level, in other provinces across Canada and at the national level, and in other countries.