Tungiasis, a neglected tropical disease caused by the sand flea Tunga penetrans, continues to affect millions of people in vulnerable communities across South America, the Caribbean, and sub-Saharan Africa. This condition causes severe pain, inflammation, disability, and social stigma, particularly among children, and can lead to long-term cognitive impairment. Despite its widespread impact, tungiasis remains largely neglected in global public health agendas. This comprehensive technical guide, grounded in the latest scientific research, offers seven evidence-based recommendations for the effective management of tungiasis. The recommendations address the most effective treatments, such as the use of low-viscosity dimethicone, particularly for severe and mild tungiasis. They also discourage some practices like the use of hydrogen peroxide and potassium permanganate and non-professional mechanical extraction in severe cases, as this common practice carries a high risk of secondary infections and physical trauma. Alternative treatments such as coconut oil combined with neem oil are encouraged, especially in resource-limited settings.