BIGG

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children

Lewinsohn, DM; Leonard, MK; LoBue, PA; Cohn, DL; Daley, CL; Desmond, E; Keane, J; Lewinsohn, DA; Loeffler, AM; Mazurek, GH; O'Brien, RJ; Pai, M; Richeldi, L; Salfinger, M; Shinnick, TM; Sterling, TR; Warshauer, DM; Woods, GL.

Clin Infect Dis.; 64 (2), 2017

BACKGROUND: Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). Tuberculosis disease is a leading cause of infectious disease morbidity and mortality...

Tuberculosis, Pulmonary/diagnosis, Latent Tuberculosis/diagnosis, Sensitivity and Specificity, Mycobacterium tuberculosis/isolation & purification, Tuberculosis/diagnosis, GRADE Approach, Tuberculin Test, Reproducibility of Results, Interferon-gamma Release Tests

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The use of molecular line probe assays for the detection of resistance to isoniazid and rifampicin

Tuberculosis (TB) remains a large-scale public health problem. Key global priorities for TB care and control include improving case-detection and detecting cases earlier, including cases of smear-negative disease. This document updates existing WHO policy on the use of molecular LPAs for detecting MTBC a...