BIGG

The use of molecular line probe assays for the detection of resistance to second-line anti-tuberculosis drugs: policy guidance

World Health Organization.

This document provides a summary of the evidence and recommendations for the use of SL-LPA for the detection of mutations associated with resistance to fluoroquinolones and SLID in patients with RR-TB and/or MDR-TB. The objectives of this policy guidance are to assess and compare the diagnostic accuracy ...

Tuberculosis, Multidrug-Resistant/diagnosis, Antibiotics, Antitubercular/pharmacology, Molecular Probe Techniques, Microbial Sensitivity Tests, Fluoroquinolones/therapeutic use, Drug Resistance, Bacterial/genetics, Genotype, Mutation, Tuberculosis, Multidrug-Resistant/genetics, Mycobacterium tuberculosis/drug effects, Mycobacterium tuberculosis/genetics

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The use of molecular line probe assays for the detection of resistance to isoniazid and rifampicin

Tuberculosis (TB) remains a large-scale public health problem. Key global priorities for TB care and control include improving case-detection and detecting cases earlier, including cases of smear-negative disease. This document updates existing WHO policy on the use of molecular LPAs for detecting MTBC a...