Manchikanti, Laxmaiah;
Kaye, Adam M;
Knezevic, Nebojsa Nick;
Giordano, James;
Applewhite, Megan K;
Bautista, Alexander;
Soin, Amol;
Blank, Susan K;
Sanapati, Mahendra R;
Karri, Jay;
Christo, Paul J;
Abd-Elsayed, Alaa;
Kaye, Alan D;
Calodney, Aaron;
Navani, Annu;
Gharibo, Christopher G;
Harned, Michael;
Gupta, Mayank;
Broachwala, Mustafa;
Sehgal, Nalini;
Kaufman, Andrew;
Wargo, Bradley;
Solanki, Daneshvari R;
Hsu, Eric S;
Limerick, Gerard;
Dennis, Allen;
Swicegood, John R;
Slavin, Konstantin;
Snook, Lee;
Pasupuleti, Ramarao;
Kosanovic, Radomir;
Justiz, Rafael;
Barkin, Robert;
Atluri, Sairam;
Shah, Shalini;
Pampati, Vidyasagar;
Helm II, Standiford;
Grami, Vahid;
Myckowiak, Vicki;
Galan, Vincent;
Singh, Vijay;
Manocha, Vivek;
Hirsch, Joshua A.
Opioid prescribing in the United States is decreasing, however, the opioid epidemic
is continuing at an uncontrollable rate. Available data show a significant number of opioid deaths,
primarily associated with illicit fentanyl use. It is interesting to also note that the data show no
clear correlation be...
Bell, Alan D;
MacCallum, Caroline;
Margolese, Shari;
Walsh, Zach;
Wright, Patrick;
Daeninck, Paul J;
Mandarino, Enrico;
Lacasse, Gary;
Deol, Jagpaul Kaur;
Freitas, Lauren de;
St. Pierre, Michelle;
Belle-Isle, Lynne;
Gagnon, Marilou;
Bevan, Sian;
Sanchez, Tatiana;
Arlt, Stephanie;
Monahan-Ellison, Max;
O'Hara, James;
Boivin, Michael;
Costiniuk, Cecilia.
One in five individuals live with chronic pain globally, which often co-occurs with sleep problems, anxiety, depression, and substance use disorders. Although these conditions are commonly managed with cannabinoid-based medicines (CBM), health care providers report lack of information on the risks, benef...
Sandbrink, Friedhelm;
Murphy, Jennifer L;
Johansson, Melanie;
Olson, Juli L;
Edens, Ellen;
Clinton-Lont, Jamie;
Sall, James;
Spevak, Christopher;
Brown, Nicole;
Guinta, Raquel;
Macedo, Franz;
Nazario, Mitchell;
Pangarkar, Sanjog;
Preston, Samuel;
Prince, Matthew;
Real, Donna Endsley;
Riegleman, David;
Steil, Evan.
In May 2022, leadership within the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) approved a joint clinical practice guideline for the use of opioids when managing chronic pain. This synopsis summarizes the recommendations that the authors believe are the most important to ...
Evidence-based recommendations on percutaneous image-guided cryoablation of peripheral neuroma for chronic pain. This involves using a needle-like probe to freeze and destroy small parts of nerves in neuromas to stop the pain signals.
Is this guidance up to date?
Next review: 2026...
Clinical question: What is the role of medical cannabis or cannabinoids for people living with chronic pain due to cancer or non-cancer causes?
Current practice: Chronic pain is common and distressing and associated with considerable socioeconomic burden globally. Medical cannabis is increasingly used t...
This guideline covers assessing all chronic pain (chronic primary pain, chronic secondary pain, or both) and managing chronic primary pain in people aged 16 years and over. Chronic primary pain is pain with no clear underlying cause, or pain (or its impact) that is out of proportion to any observable inj...
Chronic Pain/classification,
Chronic Pain/drug therapy,
Chronic Pain/prevention & control,
Antidepressive Agents/therapeutic use,
Medical Marijuana/therapeutic use,
Analgesics, Opioid/therapeutic use,
Benzodiazepines/therapeutic use,
Anticonvulsants/therapeutic use,
Anesthetics, Local/therapeutic use,
Adrenal Cortex Hormones/therapeutic use,
Acupuncture Therapy
This guideline covers prescribing of cannabis-based medicinal products for people with intractable
nausea and vomiting, chronic pain, spasticity and severe treatment-resistant epilepsy....
Manchikanti, Laxmaiah;
Kaye, Alan D;
Soin, Amol;
Albers, Sheri L;
Beall, Douglas;
Latchaw, Richard E;
Sanapati, Mahendra R;
Shah, Shalini;
Atluri, Sairam;
Abd-Elsayed, Alaa;
Abdi, Salahadin;
Aydin, Steve;
Bakshi, Sanjay;
Boswell, Mark;
Buenaventura, Ricardo;
Cabaret, Joseph;
Calodney, Aaron K;
Candido, Kenneth D;
Christo, Paul J;
Cintron, Lynn;
Diwan, Sudhir;
Gharibo, Christopher;
Grider, Jay;
Gupta, Myank;
Haney, Bill;
Harned, Michael E;
Helm II, Standiford;
Jameson, Jessica;
Jha, Sunny;
Kaye, Adam M;
Knezevic, Nebojsa Nick;
Kosanovic, Radomir;
Manchikanti, Maanasa V;
Navani, Annu;
Racz, Gabor;
Pampati, Vidyasagar;
Pasupuleti, Ramarao;
Philip, Cyril;
Rajput, Kartic;
Sehgal, Nalini;
Sudarshan, Gururau;
Vanaparthy, Rachana;
Wargo, Bradley W;
Hirsch, Joshua A.
Chronic axial spinal pain is one of the major causes of significant disability and health care costs, with facet joints as one of the proven causes of pain. To provide evidence-based guidance in performing diagnostic and therapeutic facet joint interventions. The methodology utilized included the develop...
Chronic pain in children is a significant public health problem globally and a leading
cause of morbidity in children, with a negative impact on their emotional, physical
and social development and function. The lives of families and caregivers are also
significantly impacted. Chronic pain, defined as pa...
This Web Annex provides detailed information on the processes, procedures and methods
for developing Guidelines on the management of chronic pain in children. These guidelines
were developed according to World Health Organization (WHO) guidance on guideline
development: WHO handbook for guideline develop...
