Dementia is a clinical syndrome of cognitive decline that includes a range of cognitive and
behavioural symptoms caused by a variety of underlying pathophysiological processes. This
includes Alzheimer’s disease, vascular dementia, mixed dementia, dementia with Lewy bodies and
frontotemporal dementia.1,...
Many compounding pharmacies use the phrase “bioidentical hormone” as a marketing term to imply that these preparations are natural and, thus, safer and more effective than U.S. Food and Drug Administration (FDA)–approved menopausal medications that use bioidentical or synthetic hormones or both. Ho...
Since the early 2000s, there has been a rapid
decline in colorectal cancer (CRC) mortality, due in large part
to screening and removal of precancerous polyps. Despite
these improvements, CRC remains the second leading cause
of cancer deaths in the United States, with approximately
53,000 deaths projected...
Exocrine pancreatic insufficiency (EPI) is a disorder caused by the failure of the pancreas to deliver a minimum/
threshold level of specific pancreatic digestive enzymes to the
intestine, leading to the maldigestion of nutrients and macronutrients, resulting in their variable deficiencies. EPI is freque...
Lavonas, Eric J;
Akpunonu, Peter D;
Arens, Ann M;
Babu, Kavita M;
Cao, Dazhe;
Hoffman, Robert S;
Hoyte, Christopher O;
Mazer-Amirshahi, Maryann E;
Stolbach, Andrew;
St-Onge, Maude;
Thompson, Trevonne M;
Wang, George Sam;
Hoover, Amber V;
Drennan, Ian R.
In this focused update, the American Heart Association provides updated guidance for resuscitation of patients with cardiac arrest, respiratory arrest, and refractory shock due to poisoning. Based on structured evidence reviews, guidelines are provided for the treatment of critical ...
Pavlick, Anna C;
Ariyan, Charlotte E;
Buchbinder, Elizabeth I;
Davar, Diwakar;
Gibney, Geoffrey T;
Hamid, Omid;
Hieken, Tina J;
Izar, Benjamin;
Johnson, Douglas B;
Kulkarni, Rajan P;
Luke, Jason J;
Mitchell, Tara C;
Mooradian, Meghan J;
Rubin, Krista M;
Salama, April K. S;
Shirai, Keisuke;
Taube, Janis M;
Tawbi, Hussein A;
Tolley, J Keith;
Valdueza, Caressa;
Weiss, Sarah A;
Wong, Michael K;
Sullivan, Ryan J.
Since the first approval for immune checkpoint inhibitors
(ICIs) for the treatment of cutaneous melanoma more than
a decade ago, immunotherapy has completely transformed
the treatment landscape of this chemotherapy-resistant
disease. Combination regimens including ICIs directed
against programmed cell de...
Papi, Alberto;
Ferreira, Diogenes S.;
Agache, Ioana;
Baraldi, Eugenio;
Beasley, Richard;
Brusselle, Guy;
Coleman, Courtney;
Gaga, Mina;
Gotera Rivera, Carolina Maria;
Melén, Erik;
Pavord, Ian D.;
Peñate Gómez, Deborah;
Schuermans, Daniel;
Spanevello, Antonio;
Tonia, Thomy;
Schleich, Florence.
Recent clinical trials of as-needed fixed-dose combination of inhaled corticosteroid (ICS)/formoterol have provided new evidence that may warrant a reconsideration of current practice. A Task Force was set up by the European Respiratory Society to provide evidence-based recommendations on the use of as-n...
Ra, Jin H;
Rattan, Rishi;
Patel, Nimitt J;
Bhattacharya, Bishwajit;
Butts, Christopher A;
Gupta, Shailvi;
Asfaw, Sofya H;
Como, John J;
Sahr, Sheryl M;
Bugaev, Nikolay.
Recent studies have evaluated outcomes associated with duration of antimicrobial treatment for complicated intra-abdominal infections (cIAI). The goal of this guideline was to help clinicians better define appropriate antimicrobial duration in patients who have undergone definitive source control for cIA...
Joglar, José A;
Kapa, Suraj;
Saarel, Elizabeth V;
Dubin, Anne M;
Gorenek, Bulent;
Hameed, Afshan B;
Melo, Sissy Lara de;
Leal, Miguel A;
Mondésert, Blandine;
Pacheco, Luis D;
Robinson, Melissa R;
Sarkozy, Andrea;
Silversides, Candice K;
Spears, Danna;
Srinivas, Sindhu K;
Strasburger, Janette F;
Tedrow, Usha B;
Wright, Jennifer M;
Zelop, Carolyn M;
Zentner, Dominica.
The Heart Rhythm Society (HRS) has developed expert consensus documents that have guided clinical care in the management of cardiac arrhythmias since 1996. This HRSled expert consensus statement was developed in collaboration with the American College of Cardiology (ACC), the American College of Obstetri...
On June 22, 2023, the CDC’s Advisory Committee on Immunization Practices (ACIP) recommended use of 20-valent pneumococcal conjugate vaccine (PCV20 [Prevnar 20, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.]) as an option to 15-valent pneumococcal conjugate vaccine (PCV15 [Vaxneuvance, Merck Sh...
