These guidelines focus on the treatment for infections caused by Trichomonas vaginalis, Mycoplasma genitalium and Candida albicans, and treatment for the conditions of bacterial vaginosis and anogenital warts. Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is the most common non-viral STI worldwide, is one of the most common causes of abnormal vaginal discharge and can lead to urethritis. Mycoplasma genitalium causes urethritis and cervicitis and is a particular concern due to significant antibiotic resistance (particularly to macrolides), which complicates the management and control of this infection as well as other STIs, and increases the risk of persistent infection and transmission. Candida albicans, a fungal infection which causes vulvovaginitis candidiasis, and bacterial vaginosis are the other 2 most common causes of abnormal vaginal discharge, which are not considered to be STIs, despite the potential for transmission between sexual partners. Finally, anogenital warts are prevalent and caused by certain common types of human papillomavirus (HPV), which is a common STI.