Multiple questions have been raised regarding the gastrointestinal and liver manifestations of COVID-19 infection, and implications of SARS-CoV-2 infection on gastrointestinal endoscopy. A joint society statement of the American Gastroenterological Association (AGA), the American Association for the Study of Liver Diseases (AASLD), the American College of Gastroenterology (ACG), and the American Society for Gastrointestinal Endoscopy (ASGE) on March 15, 2020 highlighted the potential for SARS-CoV-2 transmission through droplets, an established mode of transmission, and possibly fecal shedding, and the associated risk for transmission to endoscopy personnel during gastrointestinal endoscopy procedures. In this document, we seek to summarize the data and provide evidence-based recommendation and clinical guidance. This rapid recommendation document was commissioned and approved by the AGA Institute Clinical Guidelines Committee (CGC), AGA Institute Clinical Practice Updates Committee (CPUC), and the AGA Governing Board to provide timely, methodologically rigorous guidance on a topic of high clinical importance to the AGA membership and the public.