This clinical practice guideline provides evidence-informed recommendations for infection control, specimen collection, supportive care, pharmacological treatment, and prevention of complications. The recommendations are directed to all health care staff who deal with patients in emergency departments and ICUs (physicians specializing in emergency medicine, pulmonology, intensive care medicine, internal medicine, anesthesiology, infectious disease, inhalation therapists, nurses, pharmaceutical chemists). These guidelines are intended for use by decision-makers and government entities involved in the management of patients with COVID-19 in ICUs in the Region of the Americas. These guidelines do not address questions related to nutrition, physical therapy, or management of complications.