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Evidence-based recommendations on nivolumab (Opdivo) with platinum- and fluoropyrimidine-based chemotherapy for untreated HER2-negative advanced gastric, gastro-oesophageal junction or oesophageal adenocarcinoma in adults.
Commercial arrangement
There is a commercial access agreement for nivolumab...
Evidence-based recommendations on transcutaneous electrical stimulation of the trigeminal nerve for ADHD. This involves a single-use electrode patch stuck to the forehead, which sends small electrical pulses through the skin during sleep.
Is this guidance up to date?
Next review: 2026...
Evidence-based recommendations on percutaneous image-guided cryoablation of peripheral neuroma for chronic pain. This involves using a needle-like probe to freeze and destroy small parts of nerves in neuromas to stop the pain signals.
Is this guidance up to date?
Next review: 2026...
Now that the majority of people living with HIV take combination antiretroviral therapy (ART), the
spectrum of causes of pyrexia of unknown origin (PUO) has changed compared with the pre-ART era.
In these guidelines, we focus on causes and evaluation of PUO among people living with HIV with
CD4 counts <3...
Electrotherapy can be used to provide pain relief in a range of conditions including osteoarthritis. Although Transcutaneous Electrical Nerve Stimulation (TENS) was recommended as an intervention to consider in NICE Osteoarthritis guideline CG177 it is not thought to be widely used within the NHS. TENS i...
Black, Christopher;
Paine, Peter;
Agrawal, Anurag;
Aziz, Imran;
Eugenicos, Maria;
Houghton, Lesley;
Hungin, Pali;
Overshott, Ross;
Rudd, Sheryl;
Corsetti, Maura;
Ford, Alexander.
Functional dyspepsia (FD) is a common disorder of gut–brain interaction, affecting approximately 7% of individuals in the community, with most patients managed in primary care. The last British Society of Gastroenterology (BSG) guideline for the management of dyspepsia was published in 1996. In the int...
The VA and DoD Evidence-Based Practice Work Group (EBPWG) was established and
first chartered in 2004, with a mission to advise the VA/DoD Health Executive
Committee “on the use of clinical and epidemiological evidence to improve the health of
the population . . .” across the Veterans Health Administ...
Primary care clinicians should initiate patient-centred conversations with their patients about overweight or obesity. The 5As of Obesity ManagementTM (Ask-Assess-Advise-Agree-Assist) approach, starting with asking permission to discuss weight, is an appropriate format to use.
Primary care clinicians sho...
García Martín, Antonia;
Alhambra Expósito, María Rosa;
Cortés Berdonces, María;
Jódar Gimeno, Esteban;
Huguet, Isabel;
Rozas Moreno, Pedro;
Varsavsky, Mariela;
Ávila Rubio, Verónica;
Muñoz Garach, Araceli;
Muñoz Torres, Manuel.
Objective: To provide practical recommendations for the management of mineral and bone metabolism alterations in pregnancy and lactation. Participants: Members of the Working Group on Osteoporosis and Mineral Metabolism of the Spanish Society of Endocrinology and Nutrition.
Methods: Recommendations were ...
This guideline covers diagnosing and managing multiple sclerosis in people aged 18 and over. It aims to improve the quality of life for people with multiple sclerosis by promoting prompt and effective symptom management and relapse treatment, and comprehensive reviews.
NICE has also produced technology ...
Esclerosis Múltiple/terapia,
Esclerosis Múltiple/diagnóstico,
Ataxia/terapia,
Inhibidores Selectivos de la Recaptación de Serotonina/uso terapéutico,
Fatiga/terapia,
Esclerosis Múltiple/rehabilitación,
Fatiga/tratamiento farmacológico,
Limitación de la Movilidad,
Espasticidad Muscular/tratamiento farmacológico,
Distonía/tratamiento farmacológico,
Temblor/tratamiento farmacológico
