The emergence of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), has led to a global pandemic with substantial societal and economic impacts on individual persons and communities. In the United States, more than 80 million cases and more than 986,000 COVID-19-associated deaths have...
The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM‑RPG) was to formulate evidence‑based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU). We adhered to the methodology for trustworthy clinical practic...
Non-small cell lung cancer (NSCLC) is a heterogeneous disease accounting for approximately 85% of all lung cancers. Only 17% of patients are diagnosed at an early stage. Treatment is multidisciplinary and radiotherapy plays a key role in all stages of the disease. More than 50% of patients with NSCLC are...
To provide updated evidence-based recommendations for the treatment of postmenopausal osteoporosis. This guideline was developed using an a priori protocol in conjunction with a writing team consisting of two specialists in obstetrics and gynecology appointed by the ACOG Committee on Clinical Practice Gu...
This guideline provides recommendations for clinicians providing pain care, including those prescribing opioids, for outpatients aged ≥18 years. It updates the CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016 (MMWR Recomm Rep 2016;65[No. RR-1]:1–49) and includes recommen...
Oliver, Sara E;
Wallace, Megan;
See, Isaac;
Mbaeyi, Sarah;
Godfrey, Monica;
Hadler, Stephen C;
Jatlaoui, Tara C;
Twentyman, Evelyn;
Hughes, Michelle M;
Rao, Agam K;
Fiore, Anthony;
Su, John R;
Broder, Karen R;
Shimabukuro, Tom;
Lale, Allison;
Shay, David K;
Markowitz, Lauri E;
Wharton, Melinda;
Bell, Beth P;
Brooks, Oliver;
McNally, Veronica;
Lee, Grace M;
Talbot, H. Keipp;
Daley, Matthew F.
On February 27, 2021, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for the adenovirus-vectored COVID-19 vaccine (Janssen Biotech, Inc., a Janssen Pharmaceutical company, Johnson & Johnson), and on February 28, 2021, the Advisory Committee on Immunization Practices (A...
To provide updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on treatment of oligoarthritis, temporomandibular joint (TMJ) arthritis, and systemic JIA with and without macrophage activation syndrome. Recommendations regarding tapering and discontinuing treat...
Evidence and practice recommendations on the use of transanal total mesorectal excision (TaTME) for rectal cancer are conflicting. We aimed to summarize best evidence and develop a rapid guideline using transparent, trustworthy, and standardized methodology. We developed a rapid guideline in accordance w...
Fragkou, Paraskevi C;
Angelis, Giulia De;
Menchinelli, Giulia;
Can, Fusun;
Garcia, Federico;
Morfin-Sherpa, Florence;
Dimopoulou, Dimitra;
Mack, Elisabeth;
Salazar, Adolfo de;
Grossi, Adriano;
Lytras, Theodore;
Skevaki, Chrysanthi.
The present guideline has the objective of identifying the most appropriate diagnostic test and/or diagnostic/screening approach for1) patients with signs and symptoms of COVID-19; 2) travelers from areas with low and high COVID-19 prevalence, healthcare workers, and other individuals at risk for exposur...
En la actualidad, las guías basadas en la evidencia constituyen una de las herramientas más útiles para mejorar la salud pública y la práctica clínica. Su finalidad es formular intervenciones con sólidas pruebas de eficacia, evitar riesgos innecesarios, utilizar los recursos de forma eficiente, di...
