Rochwerg, Bram;
Agoritsas, Thomas;
Lamontagne, François;
Leo, Yee-Sin;
Macdonald, Helen;
Agarwal, Arnav;
Zeng, Linan;
Lytvyn, Lyubov;
Appiah, John Adabie;
Amin, Wagdy;
Arabi, Yaseen;
Blumberg, Lucille;
Burhan, Erlina;
Bausch, Frederique;
Calfee, Carolyn S;
Cao, Bin;
Cecconi, Maurizio;
Chanda, Duncan;
Cooke, Graham;
Du, Bin;
Dunning, Jake;
Geduld, Heike;
Gee, Patrick;
Hashimi, Madiha;
Hui, David S;
Kabra, Sushil;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kim, Yae-Jean;
Kissoon, Niranjan;
Kwizera, Arthur;
Laake, Jon Henrik;
Machado, Flavia R;
Mahaka, Imelda;
Manai, Hela;
Mino, Greta;
Nsutebu, Emmanuel;
Pshenichnaya, Natalia;
Qadir, Nida;
Sabzwari, Saniya;
Sarin, Rohit;
Sharland, Michael;
Shen, Yinzhong;
Ranganathan, Shalini Sri;
Souza, Joao;
Ugarte, Sebastian;
Venkatapuram, Sridhar;
Dat, Vu Quoc;
Vuyiseka, Dubula;
Wijewickrama, Ananda;
Maguire, Brittany;
Zeraatkar, Dena;
Bartoszko, Jessica;
Ge, Long;
Brignardello-Petersen, Romina;
Siemieniuk, Reed;
Guyatt, Gordon;
Diaz, Janet;
Jacobs, Michael;
Vandvik, Per Olav.
What is the role of drug interventions in the treatment of patients with covid-19? The latest version of this WHO living guidance focuses on remdesivir, following the 15 October 2020 preprint publication of results from the WHO SOLIDARITY trial. It contains a weak or conditional recommendation against th...
Rochwerg, Bram;
Agarwal, Arnav;
Zeng, Linan;
Leo, Yee-Sin;
Appiah, John Adabie;
Agoritsas, Thomas;
Bartoszko, Jessica;
Brignardello-Petersen, Romina;
Ergan, Begum;
Ge, Long;
Geduld, Heike;
Gershengorn, Hayley B;
Manai, Hela;
Huang, Minhua;
Lamontagne, François;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kurian, Linda;
Kwizera, Arthur;
Murthy, Srinivas;
Qadir, Nida;
Siemieniuk, Reed;
Silvestre, Maria Asuncion;
Vandvik, Per Olav;
Ye, Zhikang;
Zeraatkar, Dena;
Guyatt, Gordon.
Clinical question: What is the role of remdesivir in the treatment of severe covid-19? This guideline was triggered by the ACTT-1 trial published in the New England Journal of Medicine on 22 May 2020.Remdesivir has received worldwide attention as a potentially effective treatment for severe covid-19. Aft...
Helsingen, Lise M;
Vandvik, Per Olav;
Jodal, Henriette C;
Agoritsas, Thomas;
Lytvyn, Lyubov;
Anderson, Joseph C;
Auer, Reto;
Murphy, Silje Bjerkelund;
Almadi, Majid Abdulrahman;
Corley, Douglas A;
Quinlan, Casey;
Fuchs, Jonathan M;
McKinnon, Annette;
Qaseem, Amir;
Heen, Anja Fog;
Siemieniuk, Reed A C;
Kalager, Mette;
Usher-Smith, Juliet A;
Lansdorp-Vogelaar, Iris;
Bretthauer, Michael;
Guyatt, Gordon.
Recent 15-year updates of sigmoidoscopy screening trials provide new evidence on the effectiveness of colorectal cancer screening. Prompted by the new evidence, we asked: “Does colorectal cancer screening make an important difference to health outcomes in individuals initiating screening at age 50 to 7...
Bekkering, G. E;
Agoritsas, T;
Lytvyn, L;
Heen, A. F;
Feller, M;
Moutzouri, E;
Abdulazeem, H;
Aertgeerts, B;
Beecher, D;
Brito, J. P;
Farhoumand, P. D;
Ospina, N. Singh;
Rodondi, N;
van Driel, M;
Wallace, E;
Snel, M;
Okwen, P. M;
Siemieniuk, R;
Vandvik, P. O;
Kuijpers, T;
Vermandere, M.
What are the benefits and harms of thyroid hormones for adults with subclinical hypothyroidism
(SCH)? This guideline was triggered by a recent systematic review of randomised controlled trials, which could
alter practice. Current guidelines tend to recommend thyroid hormones for adults with thyroid stimu...
OBJECTIVE: To estimate benefits and harms of different colorectal cancer screening strategies, stratified by (baseline) 15-year colorectal cancer risk. DESIGN: Microsimulation modelling study using MIcrosimulation SCreening ANalysis-Colon (MISCAN-Colon).SETTING: A parallel guideline committee (BMJ Rapid ...
Siemieniuk, R. A. C;
Chu, D. K;
Kim, L. H;
Güell-Rous, M. R;
Alhazzani, W;
Soccal, P. M;
Karanicolas, P. J;
Farhoumand, P. D;
Siemieniuk, J. L. K;
Satia, I;
Irusen, E. M;
Refaat, M. M;
Mikita, J. S;
Smith, M;
Vandvik, P. O;
Agoritsas, T;
Lytvyn, L;
Guyatt, G. H.
What is the best way to use oxygen therapy for patients with an acute medical illness? A systematic review published in the Lancet in April 2018 found that supplemental oxygen in inpatients with normal oxygen saturation increases mortality.1 Its authors concluded that oxygen should be administered conser...
