Colorectal and pancreatic carcinoma are the most common cancers of the gastrointestinal tract. Their surgical treatment carries a high morbidity: Complications arise in 25% to 30% of cases, often prolonging recovery times and delaying the initiation of adjuvant therapy, leading, in turn, to worse oncolog...
Rezende, Suely M;
Neumann, Ignacio;
Angchaisuksiri, Pantep;
Awodu, Omolade;
Boban, Ana;
Cuker, Adam;
Curtin, Julie A;
Fijnvandraat, Karin;
Gouw, Samantha C;
Gualtierotti, Roberta;
Makris, Michael;
Nahuelhual, Paula;
O’Connell, Niamh;
Saxena, Renu;
Shima, Midori;
Wu, Runhui;
Rosendaal, Frits R.
Hemophilia is a rare congenital bleeding disorder that results from complete or partial deficiency of blood coagulation factor (F)VIII (hemophilia A) or FIX (hemophilia B) due to pathogenic variants in their coding genes. Hemophilia requires complex management. To date, there is no evidence-based clinica...
Smith, Sinéad M;
Boyle, Breida;
Buckley, Martin;
Costigan, Conor;
Doyle, Maeve;
Farrell, Richard;
Ismail, M. Syafiq;
Kevans, David;
Nugent, Sean;
O’Connor, Anthony;
O’Morain, Colm;
Parihar, Vikrant;
Ryan, Cristín;
McNamara, Deirdre.
There has been an increase in resistance to many of the antimicrobials used to treat Helicobacter pylori (H. pylori) nationally and internationally. Primary clarithromycin resistance and dual clarithromycin and metronidazole resistance are high in Ireland. These trends call for an evaluation of best-prac...
Pillai, Anil K;
Steigner, Michael L;
Aghayev, Ayaz;
Ahmad, Sarah;
Ferencik, Maros;
Kandathil, Asha;
Kirsch, David S;
Lee, Yoo Jin;
Nagpal, Prashant;
O’Neil, Kevin;
Partovi, Sasan;
Revels, Sha’Shonda;
Ripley, Beth;
Russell, Raymond R;
Saboo, Sachin S;
Tannenbaum, Andrew;
Thomas, Richard;
Wells, Bryan J;
Yu, Hei Shun;
Kalva, Sanjeeva P.
Pulmonary arteriovenous malformations (PAVMs) occur in 30% to 50% of patients with hereditary hemorrhagic telangiectasia. Clinical presentations vary from asymptomatic disease to complications resulting from the right to left shunting of blood through the PAVM such as paradoxical stroke, brain abscesses,...
Gravholt, Claus H;
Andersen, Niels H;
Christin-Maitre, Sophie;
Davis, Shanlee M;
Duijnhouwer, Anthonie;
Gawlik, Aneta;
Maciel-Guerra, Andrea T;
Gutmark-Little, Iris;
Fleischer, Kathrin;
Hong, David;
Klein, Karen O;
Prakash, Siddharth K;
Kanakatti Shankar, Roopa;
Sandberg, David E;
Sas, Theo C. J;
Skakkebæk, Anne;
Stochholm, Kirstine;
van der Velden, Janielle A.
Turner syndrome (TS) affects 50 per 100 000 females. TS affects multiple organs through all stages of life, necessitating multidisciplinary care. This guideline extends previous ones and includes important new advances, within diagnostics and genetics, estrogen treatment, fertility, co-morbidities, and n...
Chianelli, M;
Busetto, L;
Vettor, R;
Annibale, B;
Paoletta, A;
Papini, E;
Albanese, A;
Carabotti, M;
Casarotto, D;
De Pergola, G;
Disoteo, O E;
Grandone, I;
Medea, G;
Nisoli, E;
Raffaelli, M;
Schiff, S;
Vignati, F;
Cinquini, M;
Gonzalez-Lorenzo, M;
Fittipaldo, V A;
Minozzi, S;
Monteforte, M;
Tralongo, A C;
Novizio, R;
Persichetti, A;
Samperi, I;
Scoppola, A;
Borretta, G;
Carruba, M;
Carbonelli, M G;
De Luca, M;
Frontoni, S;
Corradini, S. G;
Muratori, F;
Attanasio, R.
This guideline (GL) is aimed at providing a clinical practice reference for the management of adult patients with overweight or obesity associated with metabolic complications who are resistant to lifestyle modification.
Surgeons, endocrinologists, gastroenterologists, psychologists, pharmacologists, a g...
Conroy, T;
Pfeiffer, P;
Vilgrain, V;
Lamarca, A;
Seufferlein, T;
O’Reilly, E. M;
Hackert, T;
Golan, T;
Prager, G;
Haustermans, K;
Vogel, A;
Ducreux, M.
The opportunity to detect pancreatic cancer (PC) when potentially curable depends on early diagnosis and an ability to identify and screen high-risk populations before symptoms arise. Identification of a high-risk population is challenging and optimal screening tools remain unclear.1 Older age is the str...
Lavonas, Eric J;
Akpunonu, Peter D;
Arens, Ann M;
Babu, Kavita M;
Cao, Dazhe;
Hoffman, Robert S;
Hoyte, Christopher O;
Mazer-Amirshahi, Maryann E;
Stolbach, Andrew;
St-Onge, Maude;
Thompson, Trevonne M;
Wang, George Sam;
Hoover, Amber V;
Drennan, Ian R.
In this focused update, the American Heart Association provides updated guidance for resuscitation of patients with cardiac arrest, respiratory arrest, and refractory shock due to poisoning. Based on structured evidence reviews, guidelines are provided for the treatment of critical ...
Seth, Rahul;
Agarwala, Sanjiv S;
Messersmith, Hans;
Alluri, Krishna C;
Ascierto, Paolo A;
Atkins, Michael B;
Bollin, Kathryn;
Chacon, Matias;
Davis, Nancy;
Faries, Mark B;
Funchain, Pauline;
Gold, Jason S;
Guild, Samantha;
Gyorki, David E;
Kaur, Varinder;
Khushalani, Nikhil I;
Kirkwood, John M;
McQuade, Jennifer Leigh;
Meyers, Michael O;
Provenzano, Anthony;
Robert, Caroline;
Santinami, Mario;
Sehdev, Amikar;
Sondak, Vernon K;
Spurrier, Gilliosa;
Swami, Umang;
Truong, Thach-Giao;
Tsai, Katy K;
van Akkooi, Alexander;
Weber, Jeffrey.
To provide guidance to clinicians regarding the use of systemic therapy for melanoma.
American Society of Clinical Oncology convened an Expert Panel and conducted an updated systematic review of the literature.
The updated review identified 21 additional randomized trials.
Neoadjuvant pembrolizumab was n...
Bell, Alan D;
MacCallum, Caroline;
Margolese, Shari;
Walsh, Zach;
Wright, Patrick;
Daeninck, Paul J;
Mandarino, Enrico;
Lacasse, Gary;
Deol, Jagpaul Kaur;
Freitas, Lauren de;
St. Pierre, Michelle;
Belle-Isle, Lynne;
Gagnon, Marilou;
Bevan, Sian;
Sanchez, Tatiana;
Arlt, Stephanie;
Monahan-Ellison, Max;
O'Hara, James;
Boivin, Michael;
Costiniuk, Cecilia.
One in five individuals live with chronic pain globally, which often co-occurs with sleep problems, anxiety, depression, and substance use disorders. Although these conditions are commonly managed with cannabinoid-based medicines (CBM), health care providers report lack of information on the risks, benef...
