Kawano-Dourado, Leticia;
Kristianslund, Eirik Klami;
Zeraatkar, Dena;
Jani, Meghna;
Makharia, Govind;
Hazlewood, Glen;
Smith, Catherine;
Jess, Tine;
Stabell, Camilla;
Schatten, Arne;
Owen, Andrew;
Gehin, Johanna;
Katsidzira, Leolin;
Weinberg, David;
Bauer-Ventura, Iazsmin;
Tugwell, Peter;
Moayyedi, Paul;
Cecchi, Ana Veronica Wolff;
Shimabuco, Andrea;
Seterelv, Siri;
Gyatt, Gordon;
Agoritsas, Thomas;
Vandvik, Per Olav.
Clinical question: In adult patients with inflammatory bowel disease, inflammatory arthritis (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis), or psoriasis taking biologic drugs, does proactive therapeutic drug monitoring (TDM) improve outcomes as compared with standard care?
Context and c...
Lamontagne, François;
Agoritsas, Thomas;
Siemieniuk, Reed;
Rochwerg, Bram;
Bartoszko, Jessica;
Askie, Lisa;
Macdonald, Helen;
Amin, Wagdy;
Bausch, Frederique Jacquerioz;
Burhan, Erlina;
Cecconi, Maurizio;
chanda, Duncan;
Quoc Dat, Vu;
Du, Bin;
Geduld, Heike;
Gee, Patrick;
Nerina, Harley;
Hashimi, Madiha;
Hunt, Beverley;
Kabra, Sushil;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kim, Yae-Jean;
Kissoon, Niranjan;
Kwizera, Arthur;
Leo, Yee-Sin;
Mahaka, Imelda;
Manai, Hela;
Mino, Greta;
Nsutebu, Emmanuel;
Pshenichnaya, Natalia;
Qadir, Nida;
Ranganathan, Shalini Sri;
Sabzwari, Saniya;
Sarin, Rohit;
Sharland, Michael;
Shen, Yinzhong;
Souza, Joao;
Stegemman, Miriam;
Ugarte, Sebastian;
Venkatapuram, Sridhar;
Vuyiseka, Dubula;
Preller, Jacobus;
Brignardello-Petersen, Romina;
Kum, Elena;
Qasim, Lyubov;
Zeraatkar, Dena;
Owen, Andrew;
Guyatt, Gordon;
Lytvyn, Lyubov;
Diaz, Janet;
Vandvik, Per;
Jacobs, Michael.
Clinical question What is the role of drugs in preventing covid-19? Why does this matter?There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline foc...
Rochwerg, Bram;
Agoritsas, Thomas;
Lamontagne, François;
Leo, Yee-Sin;
Macdonald, Helen;
Agarwal, Arnav;
Zeng, Linan;
Lytvyn, Lyubov;
Appiah, John Adabie;
Amin, Wagdy;
Arabi, Yaseen;
Blumberg, Lucille;
Burhan, Erlina;
Bausch, Frederique;
Calfee, Carolyn S;
Cao, Bin;
Cecconi, Maurizio;
Chanda, Duncan;
Cooke, Graham;
Du, Bin;
Dunning, Jake;
Geduld, Heike;
Gee, Patrick;
Hashimi, Madiha;
Hui, David S;
Kabra, Sushil;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kim, Yae-Jean;
Kissoon, Niranjan;
Kwizera, Arthur;
Laake, Jon Henrik;
Machado, Flavia R;
Mahaka, Imelda;
Manai, Hela;
Mino, Greta;
Nsutebu, Emmanuel;
Pshenichnaya, Natalia;
Qadir, Nida;
Sabzwari, Saniya;
Sarin, Rohit;
Sharland, Michael;
Shen, Yinzhong;
Ranganathan, Shalini Sri;
Souza, Joao;
Ugarte, Sebastian;
Venkatapuram, Sridhar;
Dat, Vu Quoc;
Vuyiseka, Dubula;
Wijewickrama, Ananda;
Maguire, Brittany;
Zeraatkar, Dena;
Bartoszko, Jessica;
Ge, Long;
Brignardello-Petersen, Romina;
Siemieniuk, Reed;
Guyatt, Gordon;
Diaz, Janet;
Jacobs, Michael;
Vandvik, Per Olav.
What is the role of drug interventions in the treatment of patients with covid-19? The latest version of this WHO living guidance focuses on remdesivir, following the 15 October 2020 preprint publication of results from the WHO SOLIDARITY trial. It contains a weak or conditional recommendation against th...
Rochwerg, Bram;
Agarwal, Arnav;
Zeng, Linan;
Leo, Yee-Sin;
Appiah, John Adabie;
Agoritsas, Thomas;
Bartoszko, Jessica;
Brignardello-Petersen, Romina;
Ergan, Begum;
Ge, Long;
Geduld, Heike;
Gershengorn, Hayley B;
Manai, Hela;
Huang, Minhua;
Lamontagne, François;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kurian, Linda;
Kwizera, Arthur;
Murthy, Srinivas;
Qadir, Nida;
Siemieniuk, Reed;
Silvestre, Maria Asuncion;
Vandvik, Per Olav;
Ye, Zhikang;
Zeraatkar, Dena;
Guyatt, Gordon.
Clinical question: What is the role of remdesivir in the treatment of severe covid-19? This guideline was triggered by the ACTT-1 trial published in the New England Journal of Medicine on 22 May 2020.Remdesivir has received worldwide attention as a potentially effective treatment for severe covid-19. Aft...
Baddini-Martinez, Jose;
Ferreira, Juliana;
Tanni, Suzana;
Alves, Luis;
Cabral Junior, Benedicto Francisco;
Carvalho, Carlos Roberto Ribeiro;
Cezare, Talita;
Costa, Claudia da;
Gazzana, Marcelo;
Jezler, Sergio;
Adib Kairalla, Ronaldo;
Kawano-Dourado, Leticia;
Lima, Mariana Silva;
Mancuzo, Eliane;
Moreira, Maria Auxiliadora Carmo;
Rodrigues, Marcelo Palmeira;
Rodrigues, Silvia Carla Sousa;
Rubin, Adalberto Sperb;
Lopes, Rogerio;
Steidle, Leila John Marques;
Storrer, Karin;
Baldi, Bruno Guedes.
Idiopathic pulmonary fibrosis (IPF) is a form of chronic interstitial lung disease of unknown cause, which predominantly affects elderly men who are current or former smokers. Even though it is an uncommon disease, it is of great importance because of its severity and poor prognosis. In recent decades, s...
