Carson, Jeffrey L;
Stanworth, Simon J;
Guyatt, Gordon;
Valentine, Stacey;
Dennis, Jane;
Bakhtary, Sara;
Cohn, Claudia S;
Dubon, Allan;
Grossman, Brenda J;
Gupta, Gaurav K;
Hess, Aaron S;
Jacobson, Jessica L;
Kaplan, Lewis J;
Lin, Yulia;
Metcalf, Ryan A;
Murphy, Colin H;
Pavenski, Katerina;
Prochaska, Micah T;
Raval, Jay S;
Salazar, Eric;
Saifee, Nabiha H;
Tobian, Aaron A. R;
So-Osman, Cynthia;
Waters, Jonathan;
Wood, Erica M;
Zantek, Nicole D;
Pagano, Monica B.
Red blood cell transfusion is a common medical intervention with benefits and harms. To provide recommendations for use of red blood cell transfusion in adults and children.
Standards for trustworthy guidelines were followed, including using Grading of Recommendations Assessment, Development and Evaluati...
Chung, Sharon;
Langford, Carol;
Maz, Mehrdad;
Abril, Andy;
Gorelik, Mark;
Guyatt, Gordon;
Archer, Amy;
Conn, Doyt;
Full, Kathy;
Grayson, Peter;
Mustafa, Reem.
To provide evidence-based recommendations and expert guidance for the management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Clinical questio...
Chung, Sharon;
Gorelik, Mark;
Langford, Carol;
Maz, Mehrdad;
Abril, Andy;
Guyatt, Gordon;
Archer, Amy;
Conn, Doyt;
Full, Kathy;
Grayson, Peter;
Ibarra, Maria;
Mustafa, Reem.
To provide evidence-based recommendations and expert guidance for the management of systemic polyarteritis nodosa (PAN). Twenty-one clinical questions regarding diagnostic testing, treatment, and management were developed in the population, intervention, comparator, and outcome (PICO) format for systemic...
Maz, Mehrdad;
Chung, Sharon;
Abril, Andy;
Langford, Carol;
Gorelik, Mark;
Guyatt, Gordon;
Archer, Amy;
Conn, Doyt;
Full, Kathy;
Grayson, Peter;
Ibarra, Maria;
Imundo, Lisa;
Mustafa, Reem.
To provide evidence-based recommendations and expert guidance for the management of giant cell arteritis (GCA) and Takayasu arteritis (TAK) as exemplars of large vessel vasculitis. Clinical questions regarding diagnostic testing, treatment, and management were developed in the population, intervention, c...
Clinical question What are the benefits and harms of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists when added to usual care (lifestyle interventions and/or other diabetes drugs) in adults with type 2 diabetes at different risk for cardiovascular ...
Lamontagne, François;
Agoritsas, Thomas;
Siemieniuk, Reed;
Rochwerg, Bram;
Bartoszko, Jessica;
Askie, Lisa;
Macdonald, Helen;
Amin, Wagdy;
Bausch, Frederique Jacquerioz;
Burhan, Erlina;
Cecconi, Maurizio;
chanda, Duncan;
Quoc Dat, Vu;
Du, Bin;
Geduld, Heike;
Gee, Patrick;
Nerina, Harley;
Hashimi, Madiha;
Hunt, Beverley;
Kabra, Sushil;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kim, Yae-Jean;
Kissoon, Niranjan;
Kwizera, Arthur;
Leo, Yee-Sin;
Mahaka, Imelda;
Manai, Hela;
Mino, Greta;
Nsutebu, Emmanuel;
Pshenichnaya, Natalia;
Qadir, Nida;
Ranganathan, Shalini Sri;
Sabzwari, Saniya;
Sarin, Rohit;
Sharland, Michael;
Shen, Yinzhong;
Souza, Joao;
Stegemman, Miriam;
Ugarte, Sebastian;
Venkatapuram, Sridhar;
Vuyiseka, Dubula;
Preller, Jacobus;
Brignardello-Petersen, Romina;
Kum, Elena;
Qasim, Lyubov;
Zeraatkar, Dena;
Owen, Andrew;
Guyatt, Gordon;
Lytvyn, Lyubov;
Diaz, Janet;
Vandvik, Per;
Jacobs, Michael.
Clinical question What is the role of drugs in preventing covid-19? Why does this matter?There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline foc...
Rochwerg, Bram;
Agoritsas, Thomas;
Lamontagne, François;
Leo, Yee-Sin;
Macdonald, Helen;
Agarwal, Arnav;
Zeng, Linan;
Lytvyn, Lyubov;
Appiah, John Adabie;
Amin, Wagdy;
Arabi, Yaseen;
Blumberg, Lucille;
Burhan, Erlina;
Bausch, Frederique;
Calfee, Carolyn S;
Cao, Bin;
Cecconi, Maurizio;
Chanda, Duncan;
Cooke, Graham;
Du, Bin;
Dunning, Jake;
Geduld, Heike;
Gee, Patrick;
Hashimi, Madiha;
Hui, David S;
Kabra, Sushil;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kim, Yae-Jean;
Kissoon, Niranjan;
Kwizera, Arthur;
Laake, Jon Henrik;
Machado, Flavia R;
Mahaka, Imelda;
Manai, Hela;
Mino, Greta;
Nsutebu, Emmanuel;
Pshenichnaya, Natalia;
Qadir, Nida;
Sabzwari, Saniya;
Sarin, Rohit;
Sharland, Michael;
Shen, Yinzhong;
Ranganathan, Shalini Sri;
Souza, Joao;
Ugarte, Sebastian;
Venkatapuram, Sridhar;
Dat, Vu Quoc;
Vuyiseka, Dubula;
Wijewickrama, Ananda;
Maguire, Brittany;
Zeraatkar, Dena;
Bartoszko, Jessica;
Ge, Long;
Brignardello-Petersen, Romina;
Siemieniuk, Reed;
Guyatt, Gordon;
Diaz, Janet;
Jacobs, Michael;
Vandvik, Per Olav.
What is the role of drug interventions in the treatment of patients with covid-19? The latest version of this WHO living guidance focuses on remdesivir, following the 15 October 2020 preprint publication of results from the WHO SOLIDARITY trial. It contains a weak or conditional recommendation against th...
Rochwerg, Bram;
Agarwal, Arnav;
Zeng, Linan;
Leo, Yee-Sin;
Appiah, John Adabie;
Agoritsas, Thomas;
Bartoszko, Jessica;
Brignardello-Petersen, Romina;
Ergan, Begum;
Ge, Long;
Geduld, Heike;
Gershengorn, Hayley B;
Manai, Hela;
Huang, Minhua;
Lamontagne, François;
Kanda, Seema;
Kawano-Dourado, Leticia;
Kurian, Linda;
Kwizera, Arthur;
Murthy, Srinivas;
Qadir, Nida;
Siemieniuk, Reed;
Silvestre, Maria Asuncion;
Vandvik, Per Olav;
Ye, Zhikang;
Zeraatkar, Dena;
Guyatt, Gordon.
Clinical question: What is the role of remdesivir in the treatment of severe covid-19? This guideline was triggered by the ACTT-1 trial published in the New England Journal of Medicine on 22 May 2020.Remdesivir has received worldwide attention as a potentially effective treatment for severe covid-19. Aft...
FitzGerald, John D;
Dalbeth, Nicola;
Mikuls, Ted;
Brignardello‐Petersen, Romina;
Guyatt, Gordon;
Abeles, Aryeh M;
Gelber, Allan C;
Harrold, Leslie R;
Khanna, Dinesh;
King, Charles;
Levy, Gerald;
Libbey, Caryn;
Mount, David;
Pillinger, Michael H;
Rosenthal, Ann;
Singh, Jasvinder A;
Sims, James Edward;
Smith, Benjamin J;
Wenger, Neil S;
Bae, Sangmee Sharon;
Danve, Abhijeet;
Khanna, Puja P;
Kim, Seoyoung C;
Lenert, Aleksander;
Poon, Samuel;
Qasim, Anila;
Sehra, Shiv T;
Sharma, Tarun Sudhir Kumar;
Toprover, Michael;
Turgunbaev, Marat;
Zeng, Linan;
Zhang, Mary Ann;
Turner, Amy S;
Neogi, Tuhina.
To provide guidance for the management of gout, including indications for and optimal use of urate- lowering therapy (ULT), treatment of gout ares, and lifestyle and other medication recommendation Fifty- seven population, intervention, comparator, and outcomes questions were developed, followed by a ...
Sammaritano, Lisa R;
Bermas, Bonnie L;
Chakravarty, Eliza E;
Chambers, Christina;
Clowse, Megan E. B;
Lockshin, Michael D;
Marder, Wendy;
Guyatt, Gordon;
Branch, D. Ware;
Buyon, Jill;
Christopher‐Stine, Lisa;
Crow‐Hercher, Rachelle;
Cush, John;
Druzin, Maurice;
Kavanaugh, Arthur;
Laskin, Carl A;
Plante, Lauren;
Salmon, Jane;
Simard, Julia;
Somers, Emily C;
Steen, Virginia;
Tedeschi, Sara K;
Vinet, Evelyne;
White, C. Whitney;
Yazdany, Jinoos;
Barbhaiya, Medha;
Bettendorf, Brittany;
Eudy, Amanda;
Jayatilleke, Arundathi;
Shah, Amit Aakash;
Sullivan, Nancy;
Tarter, Laura L;
Talabi, Mehret Birru;
Turgunbaev, Marat;
Turner, Amy;
D’Anci, Kristen E.
To develop an evidence-based guideline on contraception, assisted reproductive technologies (ART),
fertility preservation with gonadotoxic therapy, use of menopausal hormone replacement therapy (HRT), pregnancyassessment and management, and medication use in patients with rheumatic and musculoskeletal di...
