People with relapsed or refractory diffuse large B-cell lymphoma who cannot have an
autologous stem cell transplant usually have polatuzumab vedotin plus rituximab and
bendamustine.
The clinical evidence is from a small study that did not directly compare tafasitamab plus
lenalidomide with any other trea...
Nanchal, Rahul;
Subramanian, Ram;
Alhazzani, Waleed;
Dionne, Joanna C;
Peppard, William J;
Singbartl, Kai;
Truwit, Jonathon;
Al-Khafaji, Ali H;
Killian, Alley J;
Alquraini, Mustafa;
Alshammari, Khalil;
Alshamsi, Fayez;
Belley-Cote, Emilie;
Cartin-Ceba, Rodrigo;
Hollenberg, Steven M;
Galusca, Dragos M;
Huang, David T;
Hyzy, Robert C;
Junek, Mats;
Kandiah, Prem;
Kumar, Gagan;
Morgan, Rebecca L;
Morris, Peter E;
Olson, Jody C;
Sieracki, Rita;
Steadman, Randolph;
Taylor, Beth;
Karvellas, Constantine J.
To develop evidence-based recommendations for clinicians caring for adults with acute liver failure (ALF) or acute on chronic liver failure (ACLF) in the ICU. The guideline panel comprised 27 members with expertise in aspects of care of the critically ill patient with liver failure or methodology. We adh...
Bell, Alan D;
MacCallum, Caroline;
Margolese, Shari;
Walsh, Zach;
Wright, Patrick;
Daeninck, Paul J;
Mandarino, Enrico;
Lacasse, Gary;
Deol, Jagpaul Kaur;
Freitas, Lauren de;
St. Pierre, Michelle;
Belle-Isle, Lynne;
Gagnon, Marilou;
Bevan, Sian;
Sanchez, Tatiana;
Arlt, Stephanie;
Monahan-Ellison, Max;
O'Hara, James;
Boivin, Michael;
Costiniuk, Cecilia.
One in five individuals live with chronic pain globally, which often co-occurs with sleep problems, anxiety, depression, and substance use disorders. Although these conditions are commonly managed with cannabinoid-based medicines (CBM), health care providers report lack of information on the risks, benef...
Evidence-based recommendations on semaglutide (Wegovy) for managing overweight and obesity in adults.
Commercial availability
The Wegovy brand of semaglutide is not commercially available yet....
Evidence-based recommendations on percutaneous transluminal renal sympathetic denervation for resistant hypertension. This involves inserting a device through the skin (percutaneous) into an artery in the thigh and then into the renal arteries (transluminal). It sends radio or sound waves to destroy the ...
Evidence-based recommendations on eptinezumab (VYEPTI) for preventing migraine in adults.
Commercial arrangement
There is a simple discount patient access scheme for eptinezumab. NHS organisations can get details on the Commercial Access and Pricing (CAP) Portal. Non-NHS organisations can contact United...
Evidence-based recommendations on cannabidiol (Epidyolex) for treating seizures caused by tuberous sclerosis complex.
Commercial arrangement
There is a simple discount patient access scheme for cannabidiol. NHS organisations can get details on the Commercial Access and Pricing (CAP) Portal. Non-NHS orga...
Evidence-based recommendations on polatuzumab vedotin (Polivy) with rituximab, cyclophosphamide, doxorubicin and prednisolone for untreated diffuse large B-cell lymphoma in adults.
Commercial arrangement
There is a simple discount patient access scheme for polatuzumab vedotin. NHS organisations can get ...
Sandbrink, Friedhelm;
Murphy, Jennifer L;
Johansson, Melanie;
Olson, Juli L;
Edens, Ellen;
Clinton-Lont, Jamie;
Sall, James;
Spevak, Christopher;
Brown, Nicole;
Guinta, Raquel;
Macedo, Franz;
Nazario, Mitchell;
Pangarkar, Sanjog;
Preston, Samuel;
Prince, Matthew;
Real, Donna Endsley;
Riegleman, David;
Steil, Evan.
In May 2022, leadership within the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) approved a joint clinical practice guideline for the use of opioids when managing chronic pain. This synopsis summarizes the recommendations that the authors believe are the most important to ...
Fuxman, Claudia;
Sicilia, Beatriz;
Linares, María Eugenia;
García-López, Santiago;
Sueyro, Ramiro González;
González-Lamac, Yago;
Zabana, Yamile;
Hinojosa, Joaquín;
Barreiro-de Acosta, Manuel;
Balderramo, Domingo;
Balfour, Deborah;
Bellicoso, Maricel;
Daffra, Pamela;
Morelli, Daniela;
Orsi, Marina;
Rausch, Astrid;
Ruffinengo, Orlando;
Torok, Martín;
Sambuellir, Alicia;
Novillos, Abel;
Gomollónt, Fernando;
Paula, Juan Andrés De.
Ulcerative colitis (UC) is a chronic inflammatory disease that compromises the colon, affecting the quality of life of individuals of any age. In practice, there is a wide spectrum of clinical situations. The advances made in the physio pathogenesis of UC have allowed the development of new, more effecti...
